Regulation of dendritic cell function by Fc-γ-receptors and the neonatal Fc receptor

C Macri; H Morgan; JA Villadangos; JD Mintern

Journal article

Regulation of dendritic cell function by Fc-γ-receptors and the neonatal Fc receptor

C Macri, H Morgan, JA Villadangos, JD Mintern

Molecular Immunology | Published : 2021

DOI: 10.1016/j.molimm.2021.07.024

Abstract

Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage and to communicate with other immune cells. Among those receptors, Fc receptors (FcRs) are triggered by the Fc region of antibodies produced during adaptive immunity. In this review, the role of FcγR and neonatal Fc receptor (FcRn) in DC immunity will be discussed. Their expression in DC subsets and impact on antigen uptake and presentation, DC maturation and polarisation of T cell responses will be described. Lastly, we will discuss the importance of FcR-mediated DC function in the context of immunity during viral infection, inflammatory disease, cancer and immunotherapy.

University of Melbourne Researchers

CHRISTOPHE MACRI Author

Jose Villadangos Author

Justine Mintern Author

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Grants

Awarded by National Institutes of Health

Funding Acknowledgements

We acknowledge funding from National Health and Medical Research Council [1058193, 1154502, 1016629, 1163090, 1113293, 1161101 and 1129672] , Australian Research Council [110101383, 160103134, 190101242, 180100844, 160101373 and 180100521] , National Institutes of Health [1R01AI148407-01A1] and Human Fron-tier Science Program [0064/2011] .